There are many ways to describe a histopathological lesion, and with experience you will develop a way that suits you best. Some people choose to divide a tissue into its components and describe changes in each. For example a kidney (composed of glomeruli, tubules, and interstitium) might end up with three separate morphologic diagnoses: 1) a glomerular disease, 2) a tubular disease, and 3) an interstitial disease. Skin is another example of a tissue that can be divided in many ways: epidermis, dermis, subcutaneous tissue, follicles, sebaceous glands, apocrine glands…). Remember to look at all tissue elements on the slide, including nerves and vessels. The important thing is to be detailed and precise, and to practice!